Fabrication of injectable hydrogels based on poly(L-glutamic acid) and chitosan
作者： Shifeng Yan , Taotao Wang , Xing Li , Yuhang Jian , Kunxi Zhang
DOI: 10.1039/C7RA01864A
关键词:
摘要: Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(L-glutamic acid)/chitosan (PLGA/CS) were fabricated by self-crosslinking aldehyde-modified PLGA (PLGA–CHO) and lactic acid-modified chitosan (CS–LA). The oxidation degree PLGA–CHO substitution (DS) CS–LA could be adjusted the amount sodium periodate acid, respectively. effect solid content hydrogels, CS–LA/PLGA–CHO mass ratio on gelation time, gel content, water uptake, mechanical properties, microscopic morphology, vitro degradation was examined. pH ion sensitivity PLGA/CS also Encapsulation rabbit chondrocytes within showed viability entrapped cells cytocompatibility hydrogels. demonstrated attractive properties for future application pharmaceutical delivery tissue engineering.
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