Role of PC-1 in the etiology of insulin resistance.

摘要: : Defects in insulin receptor tyrosine kinase activity have been demonstrated tissues from resistant subjects, but mutations the gene are rare. Therefore, other molecules that capable of modulating most likely play a major role resistance. In cultured fibroblasts an patient with Type 2 diabetes, we first identified membrane glycoprotein PC-1 as inhibitor activity. is overexpressed both and without diabetes. large class II exoprotein whose function unknown. Studies muscle fat two primary for activation, reveal elevated levels inversely correlated decreased action vivo vitro. Transfection expression cells demonstrate overexpression produces impairments activity, subsequent cellular responses to insulin. These studies indicate, therefore, factor etiology resistance, potential new therapeutic target antidiabetic therapy.