Ligand-Independent Signalling Through Estrogen Receptor Pathways in Breast Cancer
作者： Jean McBryan , Leonie S. Young
DOI: 10.1007/978-3-319-17972-8_7
关键词:
摘要: Aromatase inhibitors (AIs) target the production of estrogens with intention reducing estrogen receptor signalling in breast cancer. One mechanism by which tumour cells can evade AI therapy is to find alternative ways activate absence ligand. Here we discuss mechanisms ligand-independent activation including growth factor cross talk, kinase induced phosphorylation, involvement co-factors as well hypersensitivity receptor. Understanding how cell pathways regulate activity helping identify biomarkers resistance. The research discussed here has also led development a number new treatment strategies help combat resistant disease.
springer.com
sci-hub.se 参考文章(157)
G. Bunone, P. A. Briand, R. J. Miksicek, D. Picard, Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. The EMBO Journal. ,vol. 15, pp. 2174- 2183 ,(1996) , 10.1002/J.1460-2075.1996.TB00571.X
N. J. Webster, S. Green, D. Tasset, M. Ponglikitmongkol, P. Chambon, The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. The EMBO Journal. ,vol. 8, pp. 1441- 1446 ,(1989) , 10.1002/J.1460-2075.1989.TB03526.X
Toshio Ishikawa, Koji Takano, Toshiro Fujita, Tetsuya Igarashi, Masakazu Miura, Keishi Hata, Estrogenic impurities in labware Nature Biotechnology. ,vol. 19, pp. 812- 812 ,(2001) , 10.1038/NBT0901-812
Marc Ruff, Monique Gangloff, Jean Marie Wurtz, Dino Moras, Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors. Breast Cancer Research. ,vol. 2, pp. 353- 359 ,(2000) , 10.1186/BCR80
David M. Heery, Eric Kalkhoven, Susan Hoare, Malcolm G. Parker, A signature motif in transcriptional co-activators mediates binding to nuclear receptors Nature. ,vol. 387, pp. 733- 736 ,(1997) , 10.1038/42750
K. M. Elliott, J. Dent, F. Z. Stanczyk, L. Woodley, R. C. Coombes, A. Purohit, C. Palmieri, Effects of aromatase inhibitors and body mass index on steroid hormone levels in women with early and advanced breast cancer. British Journal of Surgery. ,vol. 101, pp. 939- 948 ,(2014) , 10.1002/BJS.9477
Jian-Ping Guo, Shao-Kun Shu, Nicole N. Esposito, Domenico Coppola, John M. Koomen, Jin Q. Cheng, IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. Journal of Biological Chemistry. ,vol. 285, pp. 3676- 3684 ,(2010) , 10.1074/JBC.M109.078212
Rachel Schiff, C. Kent Osborne, Jiang Shou, Suzanne A.W. Fuqua, Estrogen Receptor: Current Understanding of Its Activation and Modulation Clinical Cancer Research. ,vol. 7, pp. 4338- 4342 ,(2001)
Stefan Westin, Riki Kurokawa, Robert T. Nolte, G. Bruce Wisely, Eileen M. McInerney, David W. Rose, Michael V. Milburn, Michael G. Rosenfeld, Christopher K. Glass, Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators Nature. ,vol. 395, pp. 199- 202 ,(1998) , 10.1038/26040
Xiao Hu, Mitchell A. Lazar, The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors Nature. ,vol. 402, pp. 93- 96 ,(1999) , 10.1038/47069