Treatment in canine epilepsy – a systematic review

摘要: Various antiepileptic drugs (AEDs) are used for the management of canine idiopathic epilepsy (IE). Information on their clinical efficacy remains limited. A systematic review was designed to evaluate existing evidence effectiveness AEDs presumptive IE. Electronic searches PubMed and CAB Direct were carried out without date or language restrictions. Conference proceedings also searched. Peer-reviewed full-length studies describing objectively in dogs with IE included. Studies allocated two groups, i.e. blinded randomized trials (bRCTs), non-blinded (nbRCTs) non-randomized (NRCTs) (group A) uncontrolled (UCTs) case series B). Individual evaluated based quality (study design, study group sizes, subject enrolment overall risk bias) outcome measures reported (in particular proportion ≥50% reduction seizure frequency). Twenty-six studies, including conference proceedings, reporting outcomes identified. Heterogeneity designs made meta-analysis inappropriate. Only four bRCTs identified considered offer higher among studies. good level supported oral phenobarbital imepitoin fair potassium bromide levetiracetam. For remaining AEDs, favorable results regarding efficacy, but there insufficient support use due lack bRCTs. Oral particular, as well levetiracetam likely be effective treatment However, variations baseline characteristics involved, significant differences between several potential sources bias preclude definitive recommendations. There is a need greater numbers adequately sized evaluating