Cytopathic Hypoxia in Sepsis: An Overview

摘要: Septic shock in humans is characterized by a hyperdynamic circulation, elevated systemic mixed-venous O2 content and lactic acidosis. An apparent defect extraction along with increased anaerobic mechanism has prompted investigation of the role hypoxia production organ dysfunction death. Although “classic” hypoxia, i.e. anemic, hypoxic, stagnant may be present at level macro- or microcirculation, there increasing evidence for “cytopathic hypoxia”, failure oxygen utilization presence adequate tissue pO2. The process cellular energy via oxidative phosphorylation discussed, general mechanisms through which it perturbed are reviewed: 1) to deliver substrate electron transport chain, 2) 3) proper coupling between flux ATP synthesis, (4) chain. first three define cytotopathic discussed in-depth, reference possible relevance human sepsis. Synergy “classic hypoxia” cytopathic hypothesized. expanding nitric oxide reactive nitrogen intermediates this highlighted.