Atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses.

摘要: Background: Vecuronium depresses carotid body chemosensitivity during hypoxia. We hypothesized that this is caused by inhibition of cholinergic transmission the body. Methods: The with its sinus nerve was removed en bloc from thiopentone-anaesthetized adult male New Zealand rabbits and perfused in vitro modified Tyrodes buffer solution at constant perfusion pressure, temperature, a pH 7.4 normocapnia. Chemoreceptor discharge spike frequencies (fx) were recorded whole after administration 500 µg nicotine, given as duplicated controls thereafter following 30 min equipotent concentrations atracurium (28.1 µM) or vecuronium(10 µM), neostigmine (9.2 µM) finally wash-out only. A short-lasting hypoxic test performed before end experimental period to confirm responsiveness validity preparation. Results: Atracurium (n = 7) vecuronium (n = 6) reduced chemoreceptor responses nicotine 70 ± 30% 66 ± 19% (SEM) (P<0.05). discharges showed full recovery group partial Finally, had fully recovered both groups. Conclusion: block nicotine-induced body.