Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.

作者: F. Fazio , L. Lionetto , G. Molinaro , H. O. Bertrand , F. Acher

DOI: 10.1124/MOL.111.074765

关键词:

摘要: … Commercial cinnabarinic acid and the cinnabarinic acid we have synthesized and used in … released extracellularly or to a rapid clearance of the compound remains to be determined. …

参考文章(45)
Yasutomi Nishizuka, Osamu Hayaishi, Enzymic synthesis of niacin nucleotides from 3-hydroxyanthranilic acid in mammalian liver. Journal of Biological Chemistry. ,vol. 238, pp. 483- 485 ,(1963) , 10.1016/S0021-9258(19)84026-7
George Paxinos, Keith B. J. Franklin, The Mouse Brain in Stereotaxic Coordinates ,(2007)
F Nicoletti, JT Wroblewski, A Novelli, H Alho, A Guidotti, E Costa, The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. The Journal of Neuroscience. ,vol. 6, pp. 1905- 1911 ,(1986) , 10.1523/JNEUROSCI.06-07-01905.1986
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Trevor W. Stone, L. Gail Darlington, Endogenous kynurenines as targets for drug discovery and development Nature Reviews Drug Discovery. ,vol. 1, pp. 609- 620 ,(2002) , 10.1038/NRD870
H. J. G. GUNDERSEN, E. B. V. JENSEN, K. KIEU, J. NIELSEN, The efficiency of systematic sampling in stereology--reconsidered. Journal of Microscopy. ,vol. 193, pp. 199- 211 ,(1999) , 10.1046/J.1365-2818.1999.00457.X
James A. Dykens, Stephen Gene Sullivan, Arnold Stern, Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate Biochemical Pharmacology. ,vol. 36, pp. 211- 217 ,(1987) , 10.1016/0006-2952(87)90691-5
Chelliah Selvam, Nadia Oueslati, Isabelle A. Lemasson, Isabelle Brabet, Delphine Rigault, Tiphanie Courtiol, Sara Cesarini, Nicolas Triballeau, Hugues-Olivier Bertrand, Cyril Goudet, Jean-Philippe Pin, Francine C. Acher, A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. Journal of Medicinal Chemistry. ,vol. 53, pp. 2797- 2813 ,(2010) , 10.1021/JM901523T
B. Wirleitner, G. Neurauter, K. Schrocksnadel, B. Frick, D. Fuchs, Interferon-γ-Induced Conversion of Tryptophan: Immunologic and Neuropsychiatric Aspects Current Medicinal Chemistry. ,vol. 10, pp. 1581- 1591 ,(2003) , 10.2174/0929867033457179