Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects on ventricular function in the normal and ischaemic heart

摘要: Epicardial electrocardiographic maps were used to assess the effect of practolol (2·5 mg/kg) on extent and severity myocardial ischaemic injury after acute coronary artery occlusion in dogs. The average ST segment elevation number sites with abnormally elevated segments significantly reduced 15 min following pretreatment when compared a previous 20 control (4·7 ± 0·5 2·9 0·6 mV 8·4 ±0·3 5·1 ±0·7, respectively). Analysis ventricular function normal conscious animals indicated lack depressant practolol, this finding was confirmed group subjected occlusions.