Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine
作者： Anne T. Nies , Katja Damme , Stephan Kruck , Elke Schaeffeler , Matthias Schwab
DOI: 10.1007/S00204-016-1728-5
关键词:
摘要: Multidrug and toxin extrusion (MATE; SLC47A) proteins are membrane transporters mediating the excretion of organic cations zwitterions into bile urine thereby contributing to hepatic renal elimination many xenobiotics. Transported substrates include creatinine as endogenous substrate, vitamin thiamine a number drug agents with in part chemically different structures such antidiabetic metformin, antiviral acyclovir ganciclovir well antibiotics cephalexin cephradine. This review summarizes current knowledge on structural molecular features human MATE including data expression localization tissues, important aspects regulation their functional role transport. The genetic variation for pharmacokinetics response will be discussed consequences personalized medicine.
springer.com
core.ac.uk 
sci-hub.se 参考文章(159)
Samantha Abel, Donald J. Nichols, Christopher J. Brearley, Malcolm D. Eve, Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide British Journal of Clinical Pharmacology. ,vol. 49, pp. 64- 71 ,(2000) , 10.1046/J.1365-2125.2000.00114.X
Atsushi Yonezawa, Ken-ichi Inui, Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics British Journal of Pharmacology. ,vol. 164, pp. 1817- 1825 ,(2011) , 10.1111/J.1476-5381.2011.01394.X
J König, O Zolk, K Singer, C Hoffmann, MF Fromm, Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. British Journal of Pharmacology. ,vol. 163, pp. 546- 555 ,(2011) , 10.1111/J.1476-5381.2010.01052.X
Kim LR Brouwer, Lauren M Aleksunes, Barbara Brandys, George P Giacoia, Gregory Knipp, Viera Lukacova, Bernd Meibohm, Sanjay K Nigam, Michael Rieder, Saskia N de Wildt, Pediatric Transporter Working Group, Susan Abdel‐Rahman, Lauren M Aleksunse, Sharyn D Baker, Michael B Bolger, Barbara Brandys, Kim LR Brouwer, Kevin T Bush, Barbara Clancy, John M DeSesso, Jeffery Fisher, Tsuyoshi Fukuda, George P Giacoia, Richard Kim, Gregory Knipp, Gideon Koren, Grace S Lee, J Steven Leeder, Viera Lukacova, Bernd Meibohm, Tomoyuki Mizuno, Miriam G Mooij, Sanjay K Nigam, Michael Rieder, Matthias Schwab, Evita van de Steeg, Margaret MS Thomson, Aksana Vasilyeva, Alexander A Vinks, Saskia N de Wildt, Wei Wu, Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical Pharmacology & Therapeutics. ,vol. 98, pp. 266- 287 ,(2015) , 10.1002/CPT.176
Jia Yin, Haichuan Duan, Yoshiyuki Shirasaka, Bhagwat Prasad, Joanne Wang, Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins Drug Metabolism and Disposition. ,vol. 43, pp. 1872- 1881 ,(2015) , 10.1124/DMD.115.066175
K Toyama, A Yonezawa, S Masuda, R Osawa, M Hosokawa, S Fujimoto, N Inagaki, K Inui, T Katsura, None, Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis British Journal of Pharmacology. ,vol. 166, pp. 1183- 1191 ,(2012) , 10.1111/J.1476-5381.2012.01853.X
Rui He, Dandan Zhang, Wei Lu, Taishan Zheng, Lili Wan, Fang Liu, Weiping Jia, SLC47A1 gene rs2289669 G > A variants enhance the glucose-lowering effect of metformin via delaying its excretion in Chinese type 2 diabetes patients Diabetes Research and Clinical Practice. ,vol. 109, pp. 57- 63 ,(2015) , 10.1016/J.DIABRES.2015.05.003
Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg, The Phyre2 web portal for protein modeling, prediction and analysis Nature Protocols. ,vol. 10, pp. 845- 858 ,(2015) , 10.1038/NPROT.2015.053
Kari M. Morrissey, Sophie L. Stocker, Eugene C. Chen, Richard A. Castro, Claire M. Brett, Kathleen M. Giacomini, The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers Clinical Pharmacokinetics. ,vol. 55, pp. 495- 506 ,(2016) , 10.1007/S40262-015-0332-9
Jana Knop, Eva Hoier, Thomas Ebner, Martin F. Fromm, Fabian Müller, Renal tubular secretion of pramipexole. European Journal of Pharmaceutical Sciences. ,vol. 79, pp. 73- 78 ,(2015) , 10.1016/J.EJPS.2015.09.004