Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment

摘要: The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective activation/up-regulation loss of function serve to impart aberrant properties, such as hyperproliferation inhibition cell death. However, a is now considered an organ-like structure, complex system composed types (e.g., cells, inflammatory endothelial fibroblasts, etc.) all embedded stroma. All these components influence each other and dynamic cross-talk, leading survival progression. As the microenvironment has crucial role pathophysiology, it represents attractive target for therapy. In this review, we describe mechanism action trabectedin plitidepsin example how specific drugs marine origin elicit their antitumor activity not only by targeting but also microenvironment.