Associations between genetic variants in vitamin D metabolism and asthma characteristics in young African Americans: a pilot study.

摘要: Introduction Low vitamin D levels have been associated with asthma severity in children. Young, urban African Americans (AAs) high rates of hypovitaminosis and asthma. Our objective was to determine associations between variants metabolism genes characteristics a pilot study young AAs. Materials Methods Two AA cohorts subjects aged 6 20 years (139 74 without asthma) were genotyped for 12 single nucleotide polymorphisms (SNPs) 3 genes: VDR (vitamin receptor), CYP24A1 (cytochrome P450 24-hydroxylase), CYP2R1 25-hydroxylase). In case-control analysis, SNPs studied an diagnosis. Within the asthmatic cohort, analyzed quantitative characteristics. All analyses adjusted age, sex, body mass index percentile. Results Only SNP rs10766197 homozygous minor genotype (P = 0.044). rs2248137 lower 0.006). multiple significant identified; rs2228570 higher nighttime morbidity scores 0.04), baseline spirometric measures Discussion This demonstrates that are young, The collection these provides evidence need large population-based D-relevant this cohort.