Pretreatment with methylprednisolone in coronary artery bypass grafting influences the levels of histamine and tryptase in serum but not in bronchoalveolar lavage fluid.

摘要: 1. The presence of histamine and tryptase in serum during after coronary artery bypass grafting may be an indication the induction inflammation. 2. One group patients received no glucocorticoids a second methylprednisolone before extracorporeal circulation. In steroid effects were seen on basal levels (2.84 +/- 0.12 ng/ml) (0.50 0.05 surgery. other two peak observed: one at 10 min starting circulation (4.19 1.79 another 4 h surgery (8.26 4.85 ng/ml). this was only elevated period (1.54 0.16 3. There differences between groups complement activation. C3a rose to 170 8% 180 10% initial value non-steroid group, respectively. 4. It concluded that mast cells activated, but since decreased post-operative period, increase level can explained by activation basophils or unknown mechanism for release not cells. 5. bronchoalveolar lavage fluid showed patients, enhanced compared with normal levels.