Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats
作者： Adolfo Cruz , Francisco J. Padillo , Eva Torres , Carmen M. Navarrete , Juan R. Muñoz-Castañeda
DOI: 10.1111/J.1600-079X.2005.00227.X
关键词:
摘要: Liver cirrhosis is a critical stage of chronic liver diseases that can produce failure, portal hypertension and hepatocarcinoma. Sustained oxidative stress plays key role in cell damage fibrosis induced during cirrhosis. We evaluated the effect regulation by melatonin on development parenchymal destruction stellate activation experimental Melatonin was administered to rats with thioacetamide (TAA) for 1 or 3 months. injury assessed serological analysis, as well hematoxylin-eosin staining situ apoptosis detection assay sections. Oxidative lipoperoxide reduced glutathione levels, measurement catalase superoxide dismutase activities serum respectively. The cells alpha-smooth muscle actin expression Our results showed TAA extensive tissue enhanced liver. prevented stress-related changes associated toxicity. In conclusion, study prevents TAA-induced rats.
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Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Jih-Chang Chen, Chip-Jin Ng, Te-Fa Chiu, Han-Ming Chen, Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion Journal of Pineal Research. ,vol. 34, pp. 260- 264 ,(2003) , 10.1034/J.1600-079X.2003.T01-1-00031.X
Nermina Jahovic, Hülya Çevik, A Özer Şehirli, Berrak Ç Yeğen, Göksel Şener, None, Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. Journal of Pineal Research. ,vol. 34, pp. 282- 287 ,(2003) , 10.1034/J.1600-079X.2003.00043.X
Yoshiji Ohta, Mutsumi Kongo, Teruaki Kishikawa, Melatonin exerts a therapeutic effect on cholestatic liver injury in rats with bile duct ligation. Journal of Pineal Research. ,vol. 34, pp. 119- 126 ,(2003) , 10.1034/J.1600-079X.2003.00018.X
Thierry Poynard, John McHutchison, Michael Manns, Christian Trepo, Karen Lindsay, Zachary Goodman, Mei–Hsiu Ling, Janice Albrecht, PEG-fibrosis project group, Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology. ,vol. 122, pp. 1303- 1313 ,(2002) , 10.1053/GAST.2002.33023
Seyithan Taysi, Mehmet Koc, Mehmet Emin Büyükokuroğlu, Konca Altınkaynak, Yaşar Nuri Şahin, Melatonin reduces lipid peroxidation and nitric oxide during irradiation‐induced oxidative injury in the rat liver Journal of Pineal Research. ,vol. 34, pp. 173- 177 ,(2003) , 10.1034/J.1600-079X.2003.00024.X
Francisco J. Padillo, Adolfo Cruz, Carmen Navarrete, Inmaculada Bujalance, Javier Briceño, José I. Gallardo, Trinidad Marchal, Rosario Caballero, Isaac Túnez, Jordi Muntané, Pedro Montilla, Carlos Pera-Madrazo, Melatonin Prevents Oxidative Stress and Hepatocyte Cell Death Induced by Experimental Cholestasis Free Radical Research. ,vol. 38, pp. 697- 704 ,(2004) , 10.1080/10715760410001705131
Diethard Müller, Manfred Sommer, Michael Kretzschmar, Thomas Zimmermann, Vyacheslav U. Buko, Oxana J. Lukivskaya, Rolf Dargel, Lipid peroxidation in thioacetamide-induced macronodular rat liver cirrhosis Archives of Toxicology. ,vol. 65, pp. 199- 203 ,(1991) , 10.1007/BF02307309
Kwan Sik Lee, Se Joon Lee, Hyo Jin Park, Jun Pyo Chung, Kwang Hyub Han, Chae Yoon Chon, Sang In Lee, Young Myoung Moon, Oxidative stress effect on the activation of hepatic stellate cells Yonsei Medical Journal. ,vol. 42, pp. 1- 8 ,(2001) , 10.3349/YMJ.2001.42.1.1
J Balkan, S Dogğru-Abbasoğlul, ö Kanbaglil, U Çevikbas, G Aykaç-Toker, M Uysal, Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress. Human & Experimental Toxicology. ,vol. 20, pp. 251- 254 ,(2001) , 10.1191/096032701678227758