Attenuation of acute and chronic liver injury by melatonin in rats

摘要: Abstract Oxidative stress produced by free radicals has been implicated in the pathogenesis of acute liver injury. The aim our study was to investigate whether melatonin, a potent antioxidant, could attenuate and chronic hepatic injury rats. Acute induced two consecutive intra peritoneal (i.p.) injections thioacetamide (TAA; 300 mg/kg, i.p.) at 24 h intervals. Chronic (TAA, i.p. for 6 weeks twice weekly, 50 mg/kg). Treatment with melatonin (3 mg/kg/daily, initiated prior post TAA intake. Rats normal control group received intra-peritoneal saline same dose frequency as those treatment groups. At end experiment, animals were sacrificed, removed weighed, ratio body weight calculated. Serum activities alanine aminotransferase (ALT), aspartate (AST), reduced glutathione (GSH) malondialdehyde (MDA) concentration homogenates assessed. We found that experiments, weight, well weight/body ratio, ALT, AST, GSH MDA lower rats treated TAA + melatonin compared Liver histology significantly improved mortality melatonin-treated decreased indicating oxidative inflammation. In conclusion both models results suggest may be utilized reduce associated stress.