Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
作者： Carmela R. Abraham , Dennis J. Selkoe , Huntington Potter
DOI: 10.1016/0092-8674(88)90462-X
关键词:
摘要: Two approaches--molecular cloning and immunochemical analysis--have identified one of the components Alzheimer's disease amyloid deposits as serine protease inhibitor alpha 1-antichymotrypsin. An antiserum against isolated Alzheimer detected immunoreactivity in normal liver. The was then used to screen a liver cDNA expression library, yielding three related clones. DNA sequence analysis showed that these clones code for Antisera purified 1-antichymotrypsin stained deposits, both situ after detergent extraction from brain. anti-amyloid recognizes at least two distinct epitopes 1-antichymotrypsin, further supporting presence this protein deposits. In addition being produced released into serum, is expressed brain, particularly areas develop lesions. Models by which could contribute development are discussed.
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