The opiate receptor and morphine-like peptides in the brain

摘要: Opiate receptors--neuronal membrane proteins that have been identified by the direct binding to membranes of radioactive opiates--have shown mediate pharmacological effects opiate drugs. Examination brain extracts for substances mimic opiates on receptor permitted identification enkephalins, two peptides, each containing five amino acids, which are normal substrates receptor. Enkephalins contained in specific neurons localized areas enriched receptors. Enkephalin-containing and receptors concentrated portions pain perception, emotional behavior, other functions altered opiates. beta-Endorphin, an opiate-like peptide 31 is pituitary gland from it can be released into circulation act presumably at peripheral target organs. In beta-endorphin hypothalamus.