Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.
作者： Rebecca Ellston , Anna Staniszewska , Nicky Whalley , Sanjay K. Pandey , Mitchell Revill
DOI: 10.1126/SCITRANSLMED.AAL5253
关键词:
摘要: … KRAS has also proven to be notoriously difficult to target with small molecules. To overcome … an antisense oligonucleotide–based therapy for inhibiting KRAS. The antisense …
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