The impact of chronic blood-brain barrier breach on intracortical electrode function.

摘要: Brain-computer interfaces (BCIs) have allowed control of prosthetic limbs in paralyzed patients. Unfortunately, the electrodes BCI that interface with brain only function for a short period time before signal quality on these becomes substantially diminished. To truly realize potential BCIs, it is imperative to chronically. In order elucidate the physiological determinants chronically functional neural interface, we studied role blood–brain barrier (BBB) electrode function, because key mediator neuronal hemostasis. We monitored status BBB and consequences breach using non-invasive imaging, electrophysiology, genomic, histological analyses. Rats implanted commercially available intracortical demonstrated an inverse correlation between performance over 16 weeks. Genomic analysis showed elicit enhanced wound healing response. Conversely, poorly functioning electrodes, chronic led local accumulation neurotoxic factors influx pro-inflammatory myeloid cells, which negatively affect health. These findings were further verified subset graded electrophysiological performance. this study, determine mechanistic link failure. Our results indicate critical physiological determinant can inform future design biochemical intervention strategies enhance longevity BCIs.