KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission
作者： Heather A. Hong , Maria Paximadis , Glenda E. Gray , Louise Kuhn , Caroline T. Tiemessen
DOI: 10.1016/J.CLIM.2013.09.005
关键词:
摘要: Abstract KIR2DS4 is the only activating gene within A haplotype, and alleles of can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish role in context HIV-1 mother-to-child transmission, we KIR genotyped 145 non-transmitting mothers (NT) their exposed uninfected infants (EU), 72 transmitting (TR) infected [intrapartum (IP), utero (IU) IU2 (an IU-enriched group)]. The frequency KIR2DS4-v was significantly higher compared to EU (P = 0.022, OR = 2.88); this association more significant amongst AA haplotypes (P = 0.004, OR = 18.4). Possession KIR2DS4-f mother with absence infant (M+I − discordance) associated a risk IP transmission (P = 0.005, OR = 3.84); whilst M − I + discordance, possession increased IU acquisition (P = 0.002; OR = 6.40). This study highlights importance transmission/acquisition.
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