'Unleashed' natural killers hinder HIV
作者： Marcus Altfeld , Philip Goulder
DOI: 10.1038/NG0607-708
关键词: Human immunodeficiency virus (HIV) 、 Virology 、 Receptor 、 Disease progression 、 Limiting 、 HLA-B Antigens 、 Biology 、 Immunology 、 Viral load 、 Acquired immunodeficiency syndrome (AIDS) 、 Allele
摘要: A new study reports that specific combinations of killer immunoglobulin-like receptor and HLA-B alleles influence AIDS progression plasma HIV RNA levels in HIV-infected individuals. These results suggest natural cells have an important role recognizing limiting infection.
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sci-hub.se 参考文章(15)
Derek Middleton, Peter Parham, Clair M. Gardiner, Geraldine M. O’Connor, Kieran J. Guinan, Rodat T. Cunningham, Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells Journal of Immunology. ,vol. 178, pp. 235- 241 ,(2007) , 10.4049/JIMMUNOL.178.1.235
Kathleen L. Collins, Benjamin K. Chen, Spyros A. Kalams, Bruce D. Walker, David Baltimore, HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes Nature. ,vol. 391, pp. 397- 401 ,(1998) , 10.1038/34929
Hathairat Thananchai, Geraldine Gillespie, Maureen P. Martin, Arman Bashirova, Nobuyo Yawata, Makoto Yawata, Philippa Easterbrook, Daniel W. McVicar, Katsumi Maenaka, Peter Parham, Mary Carrington, Tao Dong, Sarah Rowland-Jones, Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. Journal of Immunology. ,vol. 178, pp. 33- 37 ,(2007) , 10.4049/JIMMUNOL.178.1.33
Jessica A Hamerman, Kouetsu Ogasawara, Lewis L Lanier, NK cells in innate immunity. Current Opinion in Immunology. ,vol. 17, pp. 29- 35 ,(2005) , 10.1016/J.COI.2004.11.001
George B Cohen, Rajesh T Gandhi, Daniel M Davis, Ofer Mandelboim, Benjamin K Chen, Jack L Strominger, David Baltimore, The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity. ,vol. 10, pp. 661- 671 ,(1999) , 10.1016/S1074-7613(00)80065-5
Maureen P. Martin, Xiaojiang Gao, Jeong-Hee Lee, George W. Nelson, Roger Detels, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, John Trowsdale, Michael Wilson, Stephen J. O'Brien, Mary Carrington, Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS Nature Genetics. ,vol. 31, pp. 429- 434 ,(2002) , 10.1038/NG934
Matthew I. Bonaparte, Edward Barker, Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. Blood. ,vol. 104, pp. 2087- 2094 ,(2004) , 10.1182/BLOOD-2004-02-0696
Peter Parham, Immunogenetics of killer cell immunoglobulin-like receptors Molecular Immunology. ,vol. 42, pp. 459- 462 ,(2005) , 10.1016/J.MOLIMM.2004.07.027
Maureen P Martin, Ying Qi, Xiaojiang Gao, Eriko Yamada, Jeffrey N Martin, Florencia Pereyra, Sara Colombo, Elizabeth E Brown, W Lesley Shupert, John Phair, James J Goedert, Susan Buchbinder, Gregory D Kirk, Amalio Telenti, Mark Connors, Stephen J O'Brien, Bruce D Walker, Peter Parham, Steven G Deeks, Daniel W McVicar, Mary Carrington, Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 Nature Genetics. ,vol. 39, pp. 733- 740 ,(2007) , 10.1038/NG2035
Philip J. R. Goulder, David I. Watkins, HIV and SIV CTL escape: implications for vaccine design Nature Reviews Immunology. ,vol. 4, pp. 630- 640 ,(2004) , 10.1038/NRI1417