HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection
作者： Galit Alter , Suzannah Rihn , Katharine Walter , Anne Nolting , Maureen Martin
DOI: 10.1128/JVI.00256-09
关键词:
摘要: NK cells are critical in the early containment of viral infections. Epidemiological and functional studies have shown an important role expressing specific killer immunoglobulin-like receptors (KIRs) control human immunodeficiency virus type 1 (HIV-1) infection, but little is known about mechanisms that determine expansion these antiviral cell populations during acute HIV-1 infection. Here we demonstrate activating receptor KIR3DS1 + and, to a lesser extent, inhibitory KIR3DL1 specifically expand infection presence HLA-B Bw480I, putative HLA class I ligand for KIR3DL1/3DS1. These data first time subtype-dependent KIR humans.
sci-hub.se 参考文章(37)
Derek Middleton, Peter Parham, Clair M. Gardiner, Geraldine M. O’Connor, Kieran J. Guinan, Rodat T. Cunningham, Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells Journal of Immunology. ,vol. 178, pp. 235- 241 ,(2007) , 10.4049/JIMMUNOL.178.1.235
Ayotunde O. Dokun, Sungjin Kim, Hamish R.C. Smith, Hyun-Seok P. Kang, Dortha T. Chu, Wayne M. Yokoyama, Specific and nonspecific NK cell activation during virus infection Nature Immunology. ,vol. 2, pp. 951- 956 ,(2001) , 10.1038/NI714
R A Koup, J T Safrit, Y Cao, C A Andrews, G McLeod, W Borkowsky, C Farthing, D D Ho, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. Journal of Virology. ,vol. 68, pp. 4650- 4655 ,(1994) , 10.1128/JVI.68.7.4650-4655.1994
Clair M. Gardiner, Lisbeth A. Guethlein, Heather G. Shilling, Marcelo Pando, William H. Carr, Raja Rajalingam, Carlos Vilches, Peter Parham, Different NK Cell Surface Phenotypes Defined by the DX9 Antibody Are Due to KIR3DL1 Gene Polymorphism Journal of Immunology. ,vol. 166, pp. 2992- 3001 ,(2001) , 10.4049/JIMMUNOL.166.5.2992
D. Mavilio, J. Benjamin, M. Daucher, G. Lombardo, S. Kottilil, M. A. Planta, E. Marcenaro, C. Bottino, L. Moretta, A. Moretta, A. S. Fauci, Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 15011- 15016 ,(2003) , 10.1073/PNAS.2336091100
Adelheid Cerwenka, Lewis L. Lanier, Natural killer cells, viruses and cancer. Nature Reviews Immunology. ,vol. 1, pp. 41- 49 ,(2001) , 10.1038/35095564
Marcus Altfeld, Philip Goulder, 'Unleashed' natural killers hinder HIV Nature Genetics. ,vol. 39, pp. 708- 710 ,(2007) , 10.1038/NG0607-708
Sungjin Kim, Jennifer Poursine-Laurent, Steven M. Truscott, Lonnie Lybarger, Yun-Jeong Song, Liping Yang, Anthony R. French, John B. Sunwoo, Suzanne Lemieux, Ted H. Hansen, Wayne M. Yokoyama, Licensing of natural killer cells by host major histocompatibility complex class I molecules Nature. ,vol. 436, pp. 709- 713 ,(2005) , 10.1038/NATURE03847
Daniel M. Andrews, Anthony A. Scalzo, Wayne M. Yokoyama, Mark J. Smyth, Mariapia A. Degli-Esposti, Functional interactions between dendritic cells and NK cells during viral infection Nature Immunology. ,vol. 4, pp. 175- 181 ,(2003) , 10.1038/NI880
Seung-Hwan Lee, Sonia Girard, Denis Macina, Maria Busà, Ahmed Zafer, Abdelmajid Belouchi, Philippe Gros, Silvia M. Vidal, Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily Nature Genetics. ,vol. 28, pp. 42- 45 ,(2001) , 10.1038/NG0501-42