The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.
作者： George B Cohen , Rajesh T Gandhi , Daniel M Davis , Ofer Mandelboim , Benjamin K Chen
DOI: 10.1016/S1074-7613(00)80065-5
关键词: Major histocompatibility complex 、 Virology 、 Lymphokine-activated killer cell 、 Cell 、 Downregulation and upregulation 、 Interleukin 12 、 Biology 、 Lysis 、 Immunology 、 Interleukin 21 、 CTL*
摘要: To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surface infected cells. However, downregulation potentially exposes virus-infected cell to attack NK Human lymphoid cells are protected cytotoxicity primarily HLA-C and HLA-E. We present evidence that HIV-1 selectively downregulates HLA-A HLA-B but does not significantly affect or then identify residues in HLA-E protect them down-regulation. This selective allows HIV-infected cell-mediated lysis may represent a balance between escape CTL maintenance protection These results suggest subpopulations be uniquely suited combating HIV.
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