The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining
作者： Frank G. Haluska , Sheldon Finver , Yoshihide Tsujimoto , Carlo M. Croce
DOI: 10.1038/324158A0
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摘要: The reciprocal chromosome translocation, t(8;14), involving the heavy chain locus on 14 and c-myc oncogene 8 is a characteristic of B-cell malignancies Burkitt's lymphoma acute lymphoblastic leukaemia (ALL). We have cloned sequenced t(8; 14) breakpoints an African cell line, P3HR-1, pre-B ALL 380. In each case region involved has recombined with JH 14. two sites breakage lie within 70 base pairs (bp) one another. At joining site, sequences homologous to signal thought be recognized by V-D-J recombinase were identified, as N regions. chronic lymphocytic leukaemias (B-CLL) carrying t(11; translocation in follicular lymphomas t(14; 18) implicated mechanism chromosomal translocations. speculate that same enzymatic responsible for translocations ALL.
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