Acute and chronic metabolic responses of transition dairy cows with fatty liver disease to subcutaneous glucagon injections, oral glycerol, or both

摘要: This study examined the effects of multiple subcutaneous glucagon injections with or without co-administration oral glycerol on energy status-related blood metabolites and hormones Holstein dairy cows in first two wks postpartum. Twenty multiparous were fed a dry cow ration supplemented 6 kg cracked corn during period to increase likelihood developing postpartal fatty liver disease. Cows body condition score ≥ 3.5 points (1-5 point scale) assigned randomly one four treatment groups: saline, glucagon, plus glycerol, glycerol. Following treatment, serial samples collected over an 8-hr determine and/or hormones. Treatment determined by comparing concentration after administration (time 0) same compounds at time zero d 1, 7, 13 Glucagon alone tended concentrations plasma glucose 7 postpartum (P = 0.07 P 0.06, respectively) (P= 0.08), increased insulin 1 0.04 0.01, decreased nonesterified acids (NEFA) 0.04) relative saline. Administration sustained d1,