NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance.
作者： Antonio Lucena-Cacace , Masayuki Umeda , Lola E. Navas , Amancio Carnero
关键词:
摘要: Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable initiating new tumors contributing to progression, maintenance, hierarchy, complexity. GSCs highly resistant chemo radiotherapy. These believed be responsible for tumor relapses patients' fatal outcome after developing recurrent Glioblastoma (GBM) or High Grade (HGG). under replicative stress high demands on NAD+ supply repair DNA, maintain capacity induce plasticity. feeds Poly-ADP polymerases (PARP) NAD+-dependent deacetylases (SIRTUINS) GSC phenotype. This energetic core axis is mainly controlled by the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), an important oncogene dedifferentiation. Targeting depicts frontier in therapy; hence NAMPT could represent key regulator maintenance. Its inhibition may attenuate decreasing supply, consequently better together current therapies control.
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