Angiogenin Is Translocated to the Nucleus of HeLa Cells and Is Involved in Ribosomal RNA Transcription and Cell Proliferation

摘要: Angiogenin is an angiogenic protein known to play a role in rRNA transcription endothelial cells. Nuclear translocation of angiogenin cells decreases as cell density increases and ceases when are confluent. Here we report that constantly translocated the nucleus HeLa density-independent manner. Down-regulation expression by antisense RNA interference results decrease transcription, ribosome biogenesis, proliferation, tumorigenesis both vitro vivo. Exogenous rescues from inhibition. The showed constitutively into where it stimulates transcription. Thus, besides its activity, also plays cancer proliferation.