Adaptive Immunity: B Cells and Antibodies

摘要: Abstract B cells provide a variety of important functions to the adaptive immune system including antibody production, antigen presentation, and cytokine secretion, as well being required for development proper lymphoid architecture. B cells originate in bone marrow, where they mature produce an initial diverse repertoire non-self reactive B-cell receptors. After moving periphery, naive are presented with by dendritic other antigen-presenting cells. that come contact can recognize become activated, expand, further alter receptor improve specificity through somatic hypermutation affinity maturation. This is subsequently secreted active, antibody. Antibodies able bind bacteria, viruses, antigens, initiating cascade processes rid body pathogens.