Association Between Naproxen Use and Protection Against Acute Myocardial Infarction

摘要: Background The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acute myocardial infarction (AMI) is unclear. Nonsteroidal vary in their antithrombotic properties, with naproxen having a particularly effective potential. Objective To compare effect vs other NSAIDs prevention AMI an older population. Methods Population-based, matched case-control study. Patients (aged ≥65 years) Quebec had been hospitalized for January 1, 1992, December 31, 1994. admission date was considered index date. Control subjects were randomly selected from drug physician claims database. For each case, control same date, age (within 2 years), sex. Cases controls required to have at least 1 year pharmaceutical medical records before identiify risk factors exposure or nonaspirin NSAIDs. Concurrent medication defined as that Logistic regression analyses used evaluate AMI, adjusting potential confounders. Results Included study 4163 cases 14 160 controls. Determinants (adjusted odds ratios [95% confidence intervals]) included prior anticoagulants (0.76 [0.64-0.90]), nitrates (2.01 [1.86-2.17]), antidiabetic agents (1.72 [1.56-1.90]), antihypertensive (1.36 [1.28-1.45]), lipid-lowering (0.83 [0.75-0.91]), well concurrent (0.79 [0.63-0.99]). Conclusion Compared NSAIDs, has protective against AMI.