Radial Glial from mammalian developing neocortex can perform symmetric proliferative divisions in vitro

摘要: Radial Glial progenitors in the mammalian developing neocortex have been shown to follow a deterministic differentiation program restricted an asymmetric only mode of division. This feature contrasts with previous studies and other developmental systems, such as spinal cord, retina, epidermis, airway epithelium, germline, intestine, where takes place based on probabilities that can change overtime modes division are possible. Here, we combine experimental, computational theoretical tools show cultured vitro divide symmetrically, balance between different division, well cell cycle length, be modulated by external signals, Fibroblast Growth Factor. Our results suggest constraint Glia exhibit vivo may not inherent property this particular type, but induced complex organized pseudo-stratified structure neocortex. Significance Statement It is established that, during neurogenesis neocortex, asymmetrically. To understand features set important restriction, analyze cultures from mouse into terminally differentiated neurons. also symmetrically. Moreover, In conclusion, our