Serum ferritin and erythrocyte indices in iron overload

摘要: Raised levels of serum transferrin saturation (TS) and ferritin (SF) are frequently associated with increased values haemoglobin erythrocyte indices. In hereditary haemochromatosis this phenomenon has been considered to be a beneficial effect the C282Y mutation, protecting women from iron deficiency. The elevated mean corpuscular volume (MCV) in may reflect uptake synthesis by immature erythroid cells1–3. In large screening study European population, higher concentration was found homozygous either normal or TS SF4. However, when mutation analysed separately subjects different parts Europe, MCV were carriers northern Europe than those southern Europe. This could due prevalence thalassaemia trait Europe5. The variability SF depend not only on mutations HFE other genes involved haemochromatosis, but also genetic environmental factors. A recent (the HEIRS study) conducted USA Canada among Asians Pacific Islanders, who do have an H63D allele, white subjects. There is no consistent evidence supporting hypothesis that attributable liver disease diabetes. reduced Asian men explained high although further studies required clarify issue6. In anaemia chronic diseases (ACD), usually low normocytic microcytic erythrocytes. An retention active macrophages, which pathophysiological mechanism ACD, linked pro-inflammatory anti-inflammatory cytokines responsible for availability progenitors. Recently, it speculated small peptide hormone, hepcidin, might pathogenesis ACD. Hepcidin antimicrobial activity its expression increases response inflammatory stimuli. mice, hepcidin mRNA lipopolysaccharides infection. It suggested one cytokine-regulated gene impairs acquisition modifying release macrophages7. In alcoholic steatosis, unrelated deposits. cirrhosis, concentrations often detected association ferritin. These haematological findings dependent several factors, including direct indirect effects alcohol bone marrow, impaired nutritional state, stages disease. Hyperferritinaemia observed non-alcoholic fatty (NAFLD), hepatic manifestation metabolic syndrome. insulin resistance mild accumulation. So far, significant modifications indices reported NAFLD8.