Compositions and methods for less immunogenic protein formulations

作者: Robert M. Straubinger , Karthik Ramani , Vivek S. Purohit , Sathyamagalam Balasubramanian

DOI:

关键词:

摘要: Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the with a binding agent which can be serine containing compound other phosphatidyl compounds phospholipids. formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer novel lipidic structures. antigenicity imminogenicity polypeptides peptides is reduced upon formation such complexes.

参考文章(17)
Sathyamangalam V Balasubramanian, Jeremy Bruenn, Robert M Straubinger, None, Liposomes as formulation excipients for protein pharmaceuticals: a model protein study. Pharmaceutical Research. ,vol. 17, pp. 344- 350 ,(2000) , 10.1023/A:1007561308498
Mark C. Manning, Kamlesh Patel, Ronald T. Borchardt, Stability of Protein Pharmaceuticals Pharmaceutical Research. ,vol. 6, pp. 903- 918 ,(1989) , 10.1023/A:1015929109894
Charles M. Li Mutti, Tai-Wing Wu, Shirley Y. Lynn, Stabilizers for reconstituted, lyophilized samples ,(1977)
Marc Whitlow, David R. Filpula, Lihsyng Standford Lee, Robert G. L. Shorr, Polyalkylene oxide-modified single chain polypeptides ,(1998)
S. Raut, L. Weller, T. W. Barrowcliffe, Phospholipid binding of factor VIII in different therapeutic concentrates British Journal of Haematology. ,vol. 107, pp. 323- 329 ,(1999) , 10.1046/J.1365-2141.1999.01723.X
Vivek Purohit, Sathyamangalam Balasubramanian, None, Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity The AAPS Journal. ,vol. 8, pp. E362- E370 ,(2006) , 10.1007/BF02854907