A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells.

摘要: Antigen-presenting cells are key vehicles for delivering antigens in tumor immunotherapy, and the most potent of them dendritic (DCs). Recent studies have demonstrated usefulness DCs genetically modified by lipofection immune therapy, although sufficient gene transduction into is quite difficult. Here, we show that Paeoniae radix, herbal medicine, constituent, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), an attractive function to enhance phagocytosis murine cell lines, DC2.4 cells. In particular, PGG combination with lipofectin (LPF) enhanced phagocytic activity. Furthermore, efficacy cells, but not colorectal carcinoma Colon26. other words, synergistically effect lipofectin-dependent on Hence, according our data, could be effective aid using these findings provide expectation constituents from plant efficacy.