A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene.
作者： Justus B. Cohen , Arthur D. Levinson
DOI: 10.1038/334119A0
关键词:
摘要: The T24/EJ allele of the Ha-ras proto-oncogene owes its powerful oncogenic activity not merely to well documented mutation that perturbs structure encoded polypeptide, but in addition a second single nucleotide alteration an intron causes tenfold increase expression. This effect on expression is maintained upon transfer surrounding DNA heterologous gene, and as such defines novel regulatory element.
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S.A. Rosenberg, S. Hellman, V.T. De Vita, Important advances in oncology 1986 J.P. Lippincott Co.,Philadelphia, PA. ,(1986)
M W Rixon, R E Gelinas, A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell. Molecular and Cellular Biology. ,vol. 8, pp. 713- 721 ,(1988) , 10.1128/MCB.8.2.713
S Y Ng, P Gunning, R Eddy, P Ponte, J Leavitt, T Shows, L Kedes, Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes. Molecular and Cellular Biology. ,vol. 5, pp. 2720- 2732 ,(1985) , 10.1128/MCB.5.10.2720
C W Crowley, C C Liu, A D Levinson, Plasmid-directed synthesis of hepatitis B surface antigen in monkey cells. Molecular and Cellular Biology. ,vol. 3, pp. 44- 55 ,(1983) , 10.1128/MCB.3.1.44
Adeline J. Hackett, Helene S. Smith, E. Louise Springer, Robert B. Owens, Walter A. Nelson-Rees, John L. Riggs, Murray B. Gardner, Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines
2 JNCI: Journal of the National Cancer Institute. ,vol. 58, pp. 1795- 1806 ,(1977) , 10.1093/JNCI/58.6.1795
H Land, A C Chen, J P Morgenstern, L F Parada, R A Weinberg, Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Molecular and Cellular Biology. ,vol. 6, pp. 1917- 1925 ,(1986) , 10.1128/MCB.6.6.1917
R F Selden, K B Howie, M E Rowe, H M Goodman, D D Moore, Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Molecular and Cellular Biology. ,vol. 6, pp. 3173- 3179 ,(1986) , 10.1128/MCB.6.9.3173
Frances M. DeNoto, David D. Moore, Howard M. Goodman, Human growth hormone DNA sequence and mRNA structure: possible alternative splicing Nucleic Acids Research. ,vol. 9, pp. 3719- 3730 ,(1981) , 10.1093/NAR/9.15.3719
Stephen M. Mount, A catalogue of splice junction sequences Nucleic Acids Research. ,vol. 10, pp. 459- 472 ,(1982) , 10.1093/NAR/10.2.459
F.L. Graham, A.J. van der Eb, A new technique for the assay of infectivity of human adenovirus 5 DNA Virology. ,vol. 52, pp. 456- 467 ,(1973) , 10.1016/0042-6822(73)90341-3