Oncogenic Activation of Ras Proteins
作者： G. J. Clark , C. J. Der
DOI: 10.1007/978-3-642-78267-1_18
关键词:
摘要: The Discovery that the viral oncogenes carried by Harvey (v-H-ras) and Kirsten (v-K-ras) sarcoma viruses were transduced versions of normal cellular genes supported idea alterations in certain key (cellular H-, K-, N-ras) could contribute to human carcinogenesis (Ellis et al. 1981; Chang 1982b). identification transforming ras DNA isolated from tumor cells gene transfer assays confirmed this possibility (Der 1982; Parada Santos Shimizu 1983). Molecular cloning analyses these tumor-derived sequences quickly established conversion oncogenic was due simply single amino acid substitutions, primarily at residues 12 (Tabin Reddy Taparowsky 1982), 13 (Bos 1985), 61 (Yuasa Concurrent with development application sensitive molecular techniques for detection genetic point mutations DNAs finding frequently associated a broad spectrum malignancies (reviewed Bos 1988, 1989).
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