Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus.

摘要: AIDS encephalitis is a common sequela to HIV-1 infection in humans and simian immunodeficiency virus (SIVmac) macaques. Although lentiviral-infected macrophages comprise parenchymal inflammatory infiltrates affected brain tissue, the mechanisms responsible for leukocyte trafficking central nervous system are unknown. In this study, we investigated expression of various endothelial-derived adhesion proteins SIVmac-induced encephalitis. Encephalitic brains from SIVmac-infected macaques, but not uninflamed other animals, were found express abundant vascular cell molecule-1 (VCAM-1) protein on majority arteriolar, venular, capillary endothelial cells. Soluble VCAM-1 concentrations cerebrospinal fluid (CSF) encephalitic animals increased approximately 20-fold above those without Expression endothelial-related molecules, including E-selectin, P-selectin, intercellular (ICAM-1), was uniformly associated with Thus, presence both CSF disease system, may, at least part, influence monocyte lymphocyte recruitment during development Moreover, measurement soluble may assist clinical assessment or people AIDS.