The chemistry and biological potential of azetidin-2-ones.
作者： Nikhilesh Arya , Archana Y. Jagdale , Tushar A. Patil , Shradha S. Yeramwar , Sidharam S. Holikatti
DOI: 10.1016/J.EJMECH.2014.01.002
关键词:
摘要: Azetidin-2-ones, commonly referred as β-lactams, represent a unique ring system, with interesting chemistry and great biological potential. Besides its well known antibiotic activity, this system exhibits wide range of activities, attracting the attention researchers. The pharmacological profile azetidin-2-ones is reviewed here comprehensively several examples under fourteen different activity heads. methods synthesis have also been discussed.
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sci-hub.se 参考文章(169)
P M. Starkey, A J. Barrett, Human lysosomal elastase. Catalytic and immunological properties. Biochemical Journal. ,vol. 155, pp. 265- 271 ,(1976) , 10.1042/BJ1550265
John W. Todd, Textbook of clinical medicine Pitman Medical Pub.. ,(1960)
Gunda I. Georg, The Organic chemistry of β-lactams VCH Publishers. ,(1993)
Peter R. Bernstein, Philip D. Edwards, Joseph C. Williams, Inhibitors of human leukocyte elastase. Progress in Medicinal Chemistry. ,vol. 31, pp. 59- 120 ,(1994) , 10.1016/S0079-6468(08)70019-5
Dennis J. Hlasta, Edward D. Pagani, Chapter 20. Human Leukocyte Elastase Inhibitors Annual Reports in Medicinal Chemistry. ,vol. 29, pp. 195- 204 ,(1994) , 10.1016/S0065-7743(08)60733-2
Catherine J. Lee, Jack E. Ansell, Direct thrombin inhibitors. British Journal of Clinical Pharmacology. ,vol. 72, pp. 581- 592 ,(2011) , 10.1111/J.1365-2125.2011.03916.X
Nikhilesh Arya, Manoj K. Munde, Jaya Dwivedi, Archana Y. Jagdale, Kishor S. Jain, Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones. Archiv Der Pharmazie. ,vol. 346, pp. 588- 595 ,(2013) , 10.1002/ARDP.201300001
Nikhilesh Arya, Jaya Dwivedi, Vijay M. Khedkar, Evans C. Coutinho, Kishor S. Jain, Design, synthesis and biological evaluation of some 2-azetidinone derivatives as potential antihyperlipidemic agents. Archiv Der Pharmazie. ,vol. 346, pp. 872- 881 ,(2013) , 10.1002/ARDP.201300262
Sybertz Ej, Alton Kb, Yumibe Np, Davis Hr, Compton Ds, Van Heek M, McLeod Rl, In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. Journal of Pharmacology and Experimental Therapeutics. ,vol. 283, pp. 157- 163 ,(1997)
Jacalyn M. Green, Helena I.M. Boshoff, Clifton E. Barry, Jeffrey R. Deschamps, Monika I. Konaklieva, Maya B. Kostova, Carey J. Myers, Tim N. Beck, Balbina J. Plotkin, C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis Bioorganic & Medicinal Chemistry. ,vol. 19, pp. 6842- 6852 ,(2011) , 10.1016/J.BMC.2011.09.030