Process for the preparation of piperazine derivatives
作者： Katalin Nogradi , Eva Againe Csongor , Ferenc Sebok , Balint Juhasz , Laszlo Czibula
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摘要: The invention relates to a process for the preparation of trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives general formula (I) by reacting compound (III) with carbamoylchloride (II) which comprises carrying out reaction in mixture solvent and concentrated aqueous solution an alkali hydroxide at temperature between 40-100° C. presence phase transfer catalyst, separating phases washing organic layer then removing drying obtained until its weight is constant.
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