Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
作者： Alison L. Van Dyke , Michele L. Cote , Angela S. Wenzlaff , Judith Abrams , Susan Land
DOI: 10.1155/2009/242151
关键词:
摘要: In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) African American (95 103 women. Two TERT SNPs, rs2075786 rs2853677, conferred an increased of developing NSCLC, especially women, TERT-rs2735940 was associated with decreased Americans. Five 20 GHR SEPP1-rs6413428 were marginally NSCLC Caucasians. Random forest analysis reinforced importance Caucasians identified AMACR, TERT, Americans, which also significant using gene-based scores. Smoking-SNP interactions explored, haplotypes identified. The roles GHR, AMACR SEPP1 carcinogenesis warrant further exploration.
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