Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin, and Hair Growth Modulation by Neuropeptides
作者： Eva M.J. Peters , Vladimir A. Botchkarev , Natalia V. Botchkareva , Desmond J. Tobin , Ralf Paus
DOI: 10.1046/J.1523-1747.2001.01232.X
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摘要: As the neuropeptide substance P can manipulate murine hair growth in vivo , we here further studied role of sensory neuropeptides follicle biology by determining distribution and hair-cycle-dependent remodeling innervation C57BL/6 mouse back skin. Calcitonin-gene-related peptide, P, peptide histidine methionine (employed as vasoactive intestinal marker) were identified immunohistochemistry. All these markers immunolocalized to bundles nerve fibers single fibers, with distinct patterns major hair-cycle-associated changes. In epidermis around distal arrector pili muscle, only calcitonin-gene-related immunoreactive visualized, whereas largely restricted dermis subcutis. Compared telogen skin, number increased significantly (p
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