Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity
DOI: 10.1155/2010/359732
关键词:
摘要: Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities a continuum of tissue insults leading to more severe cardiometabolic renal complications including myocardial infarction end-stage-renal damage. A common denominator these is the enhanced levels cytokines like tumour necrosis factor-alpha (TNF-α), interleukin (IL-6), IL-1β resistin, which in turn activates c-Jun-N-terminal kinase (JNK) NF-κB pathways, creating vicious cycle that exacerbates insulin resistance, type-2 diabetes related complications. Emerging evidence indicates heme oxygenase (HO) inducers endowed potent anti-diabetic sensitizing effects besides their ability suppress immune/inflammatory response. Importantly, HO system abates inflammation through several mechanisms suppression macrophage-infiltration abrogation transcription factors NF-κB, JNK activating protein-1. This review highlights by potentiates signalling, particular emphasis on HO-mediated oxidative inflammatory insults. The could be explored search for novel remedies against diseases
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K Kalia, G S Dave, Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy. Cellular and Molecular Biology. ,vol. 53, pp. 68- 78 ,(2007)
J Auwerx, M B Debril, L Fajas, PPAR gamma: an essential role in metabolic control. Nutrition Metabolism and Cardiovascular Diseases. ,vol. 11, pp. 64- ,(2001)
Osama Hamdy, Sriurai Porramatikul, Ebaa Al-Ozairi, Metabolic obesity: the paradox between visceral and subcutaneous fat. Current Diabetes Reviews. ,vol. 2, pp. 367- ,(2006) , 10.2174/1573399810602040367
Gregory R Steinberg, Matthew J Watt, Mark A Febbraio, Cytokine Regulation of AMPK signalling Frontiers in Bioscience. ,vol. Volume, pp. 1902- 1916 ,(2009) , 10.2741/3350
, Geographic, ethnic, age-related and temporal variation in the incidence of end-stage renal disease in Europe, Canada and the Asia-Pacific region, 1998-2002. Nephrology Dialysis Transplantation. ,vol. 21, pp. 2178- 2183 ,(2006) , 10.1093/NDT/GFL145
Nariman Panahian, Mahin D. Maines, The heme oxygenase system and cellular defense mechanisms Advances in Experimental Medicine and Biology. ,vol. 502, pp. 249- 272 ,(2001) , 10.1007/978-1-4757-3401-0_17
Toru Kawai, Takao Masaki, Shigehiro Doi, Tetsuji Arakawa, Yukio Yokoyama, Toshiki Doi, Nobuoki Kohno, Noriaki Yorioka, PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Laboratory Investigation. ,vol. 89, pp. 47- 58 ,(2009) , 10.1038/LABINVEST.2008.104
Katia P. Karalis, Panagiotis Giannogonas, Elisavet Kodela, Yassemi Koutmani, Manolis Zoumakis, Thalia Teli, Mechanisms of obesity and related pathology: linking immune responses to metabolic stress FEBS Journal. ,vol. 276, pp. 5747- 5754 ,(2009) , 10.1111/J.1742-4658.2009.07304.X
Francisco Garcia Soriano, László Virág, Prakash Jagtap, Éva Szabó, Jon G. Mabley, Lucas Liaudet, Anita Marton, Dale G. Hoyt, Kanneganti G. K. Murthy, Andrew L. Salzman, Garry J. Southan, Csaba Szabó, Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nature Medicine. ,vol. 7, pp. 108- 113 ,(2001) , 10.1038/83241
R Feinstein, H Kanety, M Z Papa, B Lunenfeld, A Karasik, Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. Journal of Biological Chemistry. ,vol. 268, pp. 26055- 26058 ,(1993) , 10.1016/S0021-9258(19)74276-8