Population Genomic Analysis Reveals No Evidence for GC-Biased Gene Conversion in Drosophila melanogaster

作者: Matthew C. Robinson , Eric A. Stone , Nadia D. Singh

DOI: 10.1093/MOLBEV/MST220

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摘要: Gene conversion is the nonreciprocal exchange of genetic material between homologous chromosomes. Multiple lines evidence from a variety taxa strongly suggest that gene events are biased toward GC-bearing alleles. However, in Drosophila, data have largely been indirect and unclear, with some studies supporting predictions aG C-biased model other showing contradictory findings. Here, we test whether GC-biased Drosophila melanogaster using whole-genome polymorphism divergence data. Our results provide no support for thus this process unlikely to significantly contribute patterns system.

参考文章(65)
Josep M. Comeron, Ramesh Ratnappan, Samuel Bailin, The Many Landscapes of Recombination in Drosophila melanogaster PLOS Genetics. ,vol. 8, ,(2012) , 10.1371/JOURNAL.PGEN.1002905
Nicolas Galtier, Gene conversion drives GC content evolution in mammalian histones Trends in Genetics. ,vol. 19, pp. 65- 68 ,(2003) , 10.1016/S0168-9525(02)00002-1
Eugenio Mancera, Richard Bourgon, Alessandro Brozzi, Wolfgang Huber, Lars M. Steinmetz, High-resolution mapping of meiotic crossovers and non-crossovers in yeast Nature. ,vol. 454, pp. 479- 485 ,(2008) , 10.1038/NATURE07135
N. D. Singh, P. F. Arndt, A. G. Clark, C. F. Aquadro, Strong Evidence for Lineage and Sequence Specificity of Substitution Rates and Patterns in Drosophila Molecular Biology and Evolution. ,vol. 26, pp. 1591- 1605 ,(2009) , 10.1093/MOLBEV/MSP071
Nicolas Galtier, Eric Bazin, Nicolas Bierne, GC-Biased Segregation of Noncoding Polymorphisms in Drosophila Genetics. ,vol. 172, pp. 221- 228 ,(2006) , 10.1534/GENETICS.105.046524
John H. McDonald, Martin Kreitman, Adaptive protein evolution at the Adh locus in Drosophila Nature. ,vol. 351, pp. 652- 654 ,(1991) , 10.1038/351652A0
Matthew T. Webster, Laurence D. Hurst, Direct and indirect consequences of meiotic recombination: implications for genome evolution. Trends in Genetics. ,vol. 28, pp. 101- 109 ,(2012) , 10.1016/J.TIG.2011.11.002
Niclas Backström, Helene Ceplitis, Sofia Berlin, Hans Ellegren, Gene conversion drives the evolution of HINTW, an ampliconic gene on the female-specific avian W chromosome Molecular Biology and Evolution. ,vol. 22, pp. 1992- 1999 ,(2005) , 10.1093/MOLBEV/MSI198
Jonas Berglund, Katherine S Pollard, Matthew T Webster, Hotspots of Biased Nucleotide Substitutions in Human Genes PLoS Biology. ,vol. 7, pp. e1000026- ,(2009) , 10.1371/JOURNAL.PBIO.1000026