Immunity to Nerve Growth Factor Prevents Afferent Plasticity Following Urinary Bladder Hypertrophy
作者： William D. Steers , Douglas J. Creedon , Jeremy B. Tuttle
DOI: 10.1016/S0022-5347(01)66664-3
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摘要: AbstractPurpose: The goal of this investigation was to examine the effect immunity nerve growth factor (NGF) on alterations in sensory nerves from urinary bladder dorsal root ganglia (DRG) and their projections L6/S1 spinal cord following urethral obstruction rat.Materials Methods: Female Wistar rats were immunized murine 2.5S NGF, then obstructed by partial ligation for 6 weeks. Retrograde axonal tracing with FluoroGold WGA-HRP used measure areas DRG cells afferent sacral cord. Multiunit activity allowed recording micturition reflexes. Immunohistochemical staining associated protein (GAP)-43 parasympathetic nucleus (SPN) assess potential or axons Voiding frequencies measured awake NGF immune-obstructed rats.Results: Immunity prevented obstruction-induced hypertrophy neur...
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