DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis.

摘要: S100A9 and S100A8 are called damage-associated molecular pattern (DAMP) molecules because of their pro-inflammatory properties. Few studies have evaluated function as DAMP in atopic dermatitis (AD). We investigated how house-dust mites affect expression Th2 cytokine- Th17 cytokine-treated keratinocytes, secretion these affects keratinocyte-derived cytokines. Finally, we AD patients. were strongly induced IL-17A- Dermatophagoides (D.) farinae-treated respectively. Furthermore, co-treatment with D. farinae IL-17A increased compared D. farinae-Th2 cytokine co-treatment. The IL-33 mRNA level a dose-dependent manner S100A9-treated but TSLP did not change. S100A8/A9 levels also higher the lesional skin serum patients, correlated disease severity. Taken together, may be involved inducing DAMP-mediated inflammation triggered by mites.