Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA/1 mouse model of SUDEP.

摘要: Drugs that enhance the action of serotonin (5-hydroxytrypamine, 5-HT), including several selective reuptake inhibitors (SSRIs), reduce susceptibility to seizure-induced respiratory arrest (S-IRA) leads death in DBA/1 mouse model sudden unexpected epilepsy (SUDEP). However, it is not clear if specific 5-HT receptors are important these drugs and whether brain major site agents this SUDEP model. The current study examined actions affect 5-HT3 receptor subtype on S-IRA intracerebroventricular (ICV) microinjection an SSRI would mice. data indicate systemic administration SR 57227, a agonist, was effective blocking doses did block seizures, effect SSRI, fluoxetine, abolished by coadministration antagonist, ondansetron. Intracerebroventricular fluoxetine present also able without seizures. These findings suggest play role serotonergic agents, such as SSRIs, which consistent with abnormal expression brainstem DBA mice observed previously. Taken together, systemically administered act, at least, part, brain, may be effect.