Vasopressin alone or with epinephrine may be superior to epinephrine in a clinically relevant porcine model of pulseless electrical activity cardiac arrest.

作者: Charles M. Little , Mia H. Marietta , Kathleen Peng , Kennon Heard , Miguel Fragoso

DOI: 10.1016/J.AJEM.2006.05.002

关键词:

摘要: Cardiac arrest remains an important entity in the clinical field. In United States, annually there are about 450,000 sudden cardiac deaths prehospital or ED setting [1]. Current survival rates 5% to 10% of cases, as reported a recent European multicenter trial [2]. The presenting rhythm has changed over last decade. incidence primary ventricular fibrillation (VF) is decreasing and pulseless electrical activity (PEA) increasing [3]. widespread introduction automated external defibrillators lay can be expected increase postcounter shock PEA. Pulseless worse prognosis than VF Epinephrine currently recommended medical therapy for PEA [4]. increases coronary perfusion pressure (CoPP) myocardial perfusion.

参考文章(25)
CHARLES G. BROWN, RONALD B. TAYLOR, HOWARD A. WERMAN, TUAN LUU, GENEVIEVE SPITTLER, ROBERT L. HAMLIN, Effect of standard doses of epinephrine on myocardial oxygen delivery and utilization during cardiopulmonary resuscitation. Critical Care Medicine. ,vol. 16, pp. 536- 539 ,(1988) , 10.1097/00003246-198805000-00013
Karl H. Lindner, Friedrich W. Ahnefeld, Winfried Schuermann, Ingrid M. Bowdler, Epinephrine and norepinephrine in cardiopulmonary resuscitation. Effects on myocardial oxygen delivery and consumption Chest. ,vol. 97, pp. 1458- 1462 ,(1990) , 10.1378/CHEST.97.6.1458
H R Halperin, J E Tsitlik, A D Guerci, E D Mellits, H R Levin, A Y Shi, N Chandra, M L Weisfeldt, Determinants of blood flow to vital organs during cardiopulmonary resuscitation in dogs. Circulation. ,vol. 73, pp. 539- 550 ,(1986) , 10.1161/01.CIR.73.3.539
Wolfgang G. Voelckel, Keith G. Lurie, Scott McKnite, Todd Zielinski, Paul Lindstrom, Colleen Peterson, Anette C. Krismer, Karl H. Lindner, Volker Wenzel, Comparison of epinephrine and vasopressin in a pediatric porcine model of asphyxial cardiac arrest. Critical Care Medicine. ,vol. 28, pp. 3777- 3783 ,(2000) , 10.1097/00003246-200012000-00001
Viktoria D. Mayr, Volker Wenzel, Wolfgang G. Voelckel, Anette C. Krismer, Tilko Mueller, Keith G. Lurie, Karl H. Lindner, Developing a Vasopressor Combination in a Pig Model of Adult Asphyxial Cardiac Arrest Circulation. ,vol. 104, pp. 1651- 1656 ,(2001) , 10.1161/HC3901.095896
R. V Ditchey, Y. Goto, J. Lindenfeld, Myocardial oxygen requirements during experimental cardiopulmonary resuscitation. Cardiovascular Research. ,vol. 26, pp. 791- 797 ,(1992) , 10.1093/CVR/26.8.791
Emanuel P. Rivers, Jacobo Wortsman, Mohamed Y. Rady, Heidi C. Blake, Francis T. McGeorge, Nancy M. Buderer, The Effect of the Total Cumulative Epinephrine Dose Administered During Human CPR on Hemodynamic, Oxygen Transport, and Utilization Variables in the Postresuscitation Period Chest. ,vol. 106, pp. 1499- 1507 ,(1994) , 10.1378/CHEST.106.5.1499
Norman A Paradis, Gerard B Martin, Emanuel P Rivers, Mark G Goetting, Timothy J Appleton, Marcia Feingold, Richard M Nowak, Coronary Perfusion Pressure and the Return of Spontaneous Circulation in Human Cardiopulmonary Resuscitation JAMA: The Journal of the American Medical Association. ,vol. 263, pp. 1106- 1113 ,(1990) , 10.1001/JAMA.1990.03440080084029