Transformation by v-Myb.

摘要: The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia animals and transforms hematopoietic cells culture. AMV was discovered 1930s as a caused disease chickens similar to myelogenous humans (Hall et al., 1941). This retrovirus played an important role history cancer research for two reasons. First, used demonstrate all oncogenic viruses did not contain single cancer-causing principle. In particular, although both Rous sarcoma (RSV) could replicate cultures either embryonic fibroblasts or cells, RSV transform whereas (Baluda, 1963; Durban Boettiger, 1981a). Second, infected with develop remarkably high white counts therefore their peripheral blood contains large quantities viral particles (Beard, 1963). For this reason often prototypic order study assembly later produce amounts reverse transcriptase commercial purposes. Following discovery v-src demonstration arose from normal c-src proto-oncogene, number were analysed by techniques found also cellular origin (Roussel 1979). case AMV, shown almost entire retroviral env gene had been replaced sequence (initially called mab amv, but renamed v-myb) (Duesberg 1980; Souza 1980). Remarkably, sequences contained myb shared between E26 virus, any other acutely transforming retroviruses. addition, second (ets) unique. first described 1960s erythroblastosis chickens, more reminiscent (AEV) than (Ivanov 1962).