Calcium and sodium handling during volume expansion in essential hypertension
作者： P. Coruzzi , A. Biggi , L. Musiari , R. Ceriati , G.L. Mossini
DOI: 10.1016/0026-0495(93)90134-A
关键词:
摘要: To evaluate the actual role of extracellular fluid volume (ECFV) expansion per se in modulating rate urinary calcium excretion, a thermoneutral water immersion (WI) study was conducted 10 normal subjects and 30 patients with essential hypertension. Central hypervolemia by 2 hours WI caused significant diuretic natriuretic response (P < .005) subjects; no changes were detected magnesium excretion. provoked either an appropriate or exaggerated natriuresis .001) 21 hypertensive patients; these also exhibited highly positive correlation between sodium excretion during .001). In remaining nine patients, produced response, but barely discernible = NS) (inappropriate response). These reduction .01) The data indicate that (1) may have regulating (2) leak be attributable to close relationship metabolism, causally related disturbance homeostasis
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