Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures.

作者: Robert J. Hamm

DOI: 10.1089/089771501317095241

关键词:

摘要: Neurobehavioral assessment of outcome has played an integral part in traumatic brain injury (TBI) research. Given the fundamental role neurobehavioral measurement, it is critical that tasks used are highest psychometric quality. The purpose this paper to evaluate several, commonly measures along dimensions reliability, sensitivity, and validity. Using both midline lateral fluid-percussion models, nine were evaluated assessed three different constructs. Reflex suppression was measured by duration pinna, corneal, righting reflexes. Vestibulomotor function with beam-balance, beam-walking, rotorod tasks. Cognitive Morris water maze performance (goal latency, path length, cumulative distance). evaluation reliability found all had acceptably high coefficients (0.79 or higher). analysis each measure's sensitivity capable detecting injury-induced impairments. However, there some substantial differences vestibulomotor performance: most sensitive measure goal latency length equally performance. In validity, results a factor supported convergent discriminative validity measures. And cases which preclinical clinical research have same construct, animal model predictive (or external) Thus, according standards measurement instruments evaluated, indicated these provide valid after fluid percussion TBI.

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