Wheat bran and corn oil do not influence proliferation in the colon of healthy rats when energy intakes are equivalent.

摘要: Dietary intakes of fiber (wheat bran) and fat (corn oil) by rats were quantitatively varied for 6 wk while energy essential nutrients constant among the diets. The influence wheat bran corn oil levels on colonic epithelial cell proliferation was assessed using [3H]thymidine incorporation assays. Cellular in cecum, proximal colon distal not significantly higher when healthy consumed low comparison to high diets, nor diets Additionally, there no significant interactions between these variables. In caused a lower pH luminal contents cecum colon, but differences total short-chain fatty acid concentrations cecal digesta. These results suggest that are equivalent or diet do cause biological changes mucosa may be associated with increased risk cancer.