Cellular proliferation in proximal and distal rat colon during 1,2-dimethylhydrazine-induced carcinogenesis
作者： T.J. McGarrity , L.P. Peiffer , P.C. Colony
DOI: 10.1016/0016-5085(88)90489-1
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摘要: Abstract Sequential changes in proliferative parameters proximal and distal colonic crypts were studied during 1,2-dimethylhydrazine-induced carcinogenesis using [ 3 H]thymidine autoradiography as a probe. 1,2-dimethylhydrazine (20 mg/kg) vehicle (ethylenediaminetetraacetic acid) control rats received weekly s.c. injections for 20 wk. All animals pulse of before death at weeks 2, 6, 10, 16, 22, 26, or 30. In addition, 8 unexposed to served baseline controls. Dramatic regional differences noted the Crypt length, labeling index, zone size all significantly greater distally than proximally (p
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